Of great relevance to the present study was that, in the reconstructed intestinal equivalents, the administration of SPD+EUG for 24 h exerted anti-CRC effects (reduced CEA marker and proliferation) on the embedded SW620/Caco-2 spheroids, whilst simultaneously exerting beneficial effects to the normal, co-cultured NCM640 enterocytes. The gene discussed is CEACAM5; the disease is colorectal carcinoma.