Although the present study did not identify the molecular mechanisms behind the anti-CRC effect of EUG, it was shown that EUG alone (100 μM) reduced cell proliferation, viability, and spheroid area, and increased the percentage of apoptotic caspase-3/7, Annexin V-, and TUNEL-positive cells in both SW620 and Caco-2 homotypic spheroids, compared to the untreated CTRLs. Here, CASP3 is linked to colorectal carcinoma.