HMGCR and neoplasm: Studies propose that inhibition of the enzyme HMG-CoA reductase inhibits cholesterol synthesis and, consequently, the reduction of tumor androgen signaling; this results in a decrease in lipid rafts in tumor cells and the lack of prenylation of G, Ras, and Rho proteins by reducing the synthesis of intermediates such as geranyl pyrophosphate and farnesyl pyrophosphate [27,28,29].