KCNH2 and Familial short QT syndrome: In a more recent study, Bains et al. [38] followed a “suppression-and-replacement” (“SupRep”) approach with shRNAs to restore the APD of hiPSC-CMs with loss-or-function or gain-of-function mutations in KCNH2, associated with long QT syndrome type 2 and short QT syndrome type 1 and thus exhibiting a reduced or an increased IKr, respectively.