BCL2 and central nervous system cancer: PTE effectively inhibits the proliferation of various glioma cell lines (T98G, LN18, U87, LN229, and C6) in a dose- and time-dependent manner, inducing intrinsic mitochondria-mediated apoptosis as evidenced by increased levels of cleaved caspase-3, -9, and PARP-1, along with altered Bax, Bcl-2, and Survivin protein levels [184].