Combining RVS and TMZ not only reduces STAT3 activity but also increases the expression of negative regulators of STAT3, such as PIAS3, SHP1, SHP2, and SOCS3, further supporting Res’s inhibitory effect on the JAK-STAT pathway and its potential to improve chemosensitivity in GBM cells. This evidence concerns the gene SOCS3 and glioblastoma.