Although the in vitro cell models lack the complexity of the in vivo systems, such as the interactions within the bone marrow microenvironment and the dynamics of systemic pharmacodynamics, they have been proven to be valuable in the study of CSA caused by mutations in HSCB [30], ABCB7 [31], ALAS2 [32], and GLRX5 [33] genes. The gene discussed is HSCB; the disease is chromosome-type aberration frequency.