UCP1 and obesity due to melanocortin 4 receptor deficiency: The results of the second research group showed that miglitol directly enhances beta3-adrenergic signaling by increasing UCP1 mRNA and protein expression and the expression of four proteins involved in the signaling cascade (PKA, HSL, P38alphaMAPK and PGC1 alpha) in mice with obesity induced by high-fat diet [116].