CAPN8 and neoplasm: In contrast, the ‘tumor cells 2’ cluster was characterized by genes associated with protein synthesis (Cmss1, Rpph1, Rps12, Lars2, Ncl2), tumorigenesis (Mt-Rnr2, Hmga2, Mab1b) and cell–cell communication (Gphn, Camk1d, Il31ra, Cmss1, Rpph1) (Figure 3A), which may be indicative of an inflammatory phenotype.