In addition, ALL-MSCs’ secretome lacked proteins essential for endothelial proliferation, the regulation of platelet activation, response to vitamin D, the chemotaxis and migration of blood cells, the regulation of growth and other vital functions: CCL5, CTSB, CTSC, CTSF, CXCL1, CXCL8, EGFR, FABP5, ICAM1, FGFR1, FTL, HGF, HLA-DQ, IGF2, IGF2R, MET, SERPINA3, LTBP4, PDGFRB, SF3B1, SPP1, TGFB1, TGFB2 and YAP1. Here, SPP1 is linked to acute lymphoblastic leukemia.