In this review, PubMed, Google Scholar, Web of Science, and Scopus were searched using the key words “neuropeptide FF”, “NPFF”, “neuropeptide”, and “RFamide peptide” with “hypertension”, “essential hypertension”, “blood pressure”, “NPFF receptor”, “GPCR”, “signaling”, “signal transduction”, “brain”, “central nervous system”, “CNS”, “kidney”, and “renal” in various combinations with no date limitation until April 2024. The gene discussed is NPFF; the disease is Hypertension.