For our experiments, we chose three cell lines that are characterized by their high expression of the IL6R gene and the presence of a membrane form of IL-6R capable of responding to IL-6 application by triggering classic signaling, namely the HepG2 hepatocellular carcinoma cell line [43], the myeloma cell line U-266 [44], and the pancreatic carcinoma ductal origin PANC-1 cell line [45]. Here, IL6R is linked to hepatocellular carcinoma.