It is known that angiotensin II, the main effector peptide of the renin-angiotensin system, can have a profibrotic effect after binding to the angiotensin II type 1 (AT1) receptor in hypertension, directly or via the induction of transforming growth factor-beta 1 (TGF-ß1) and/or PAI-1; consequently, AT1 receptor blockade reduces renal PAI-1 expression induced by angiotensin II infusion [12,13]. The gene discussed is AGT; the disease is Hypertension.