HMGA1 and viral infectious disease: Here, we showed that HMGA1, a non-histone chromatin regulator, may play a significant role in counteracting virus infection-induced DNA damage, as the siRNA-mediated knockdown of HMGA1 protein expression or inhibition of HMGA1 activity by the chemical inhibitor Netropsin uniformly exacerbates the DNA damage induced by BoHV-1 productive infection (Figure 2 and Figure 3).