By analyzing gene expression data from a public database, we found that HPV-positive lung SQCs significantly increased SLC7A11 expression when compared to HPV-negative laryngeal squamous cell carcinomas (LSCCs), cervical squamous cell carcinomas (CSCCs) and oropharyngeal squamous cell carcinomas (OPSCCs). The gene discussed is SLC7A11; the disease is laryngeal squamous cell carcinoma.