The role of the administration of rPKM2 in protecting cardiomyocyte from apoptosis and promoting cardiomyocyte proliferation is in concordance with our previous observations: (1) EcPKM2 facilitates tumor growth [28] and cutaneous wound healing [29]; and (2) EcPKM2 facilitates organ tissue fibrosis progression by promoting myofibroblasts apoptosis resistance and upregulating Arg-1 expression via activating integrin αvβ3. This evidence concerns the gene ARG1 and neoplasm.