NFE2L2 and cancer: In addition, Nrf2 confers resistance to ferroptosis by inducing key enzymes of glutathione synthesis and metabolism, suppresses p53-induced senescence, and protects telomeres from DNA damage caused by oxidative stress [65,66]; furthermore, it induces angiogenesis and activates invasion and metastasis through the downregulation of E-cadherin expression and by promoting epithelial-to-mesenchymal transition (EMT) [67]; finally, it allows cancer cells to avoid immune destruction and it inhibits the production of antitumor cytokines, such as IFN-γ [68].