The study demonstrated a significant inverse Pearson correlation between KEAP1 methylation and transcription levels, with pharmacological treatment (5-azacytidine) restoring KEAP1 expression in three of the four ccRCC cell lines used in the study (ccRCC FG-2, ccRCC FW, and ccRCC 5). The gene discussed is KEAP1; the disease is nonpapillary renal cell carcinoma.