However, in cancer cells, abnormal activation of the HGF/c-Met axis, often linked to c-Met gene mutations, overexpression, and amplification, drives tumor development and progression by stimulating multiple signaling pathways, including PI3K/AKT, Ras/MAPK, JAK/STAT, and Wnt/β-catenin [141]. The gene discussed is AKT1; the disease is neoplasm.