Notably, increased chromatin condensation and heterochromatin detachment from the INM have been observed in skeletal muscle samples from TOR1AIP1 patients with muscular dystrophy [23,29,30] and congenital myasthenic syndrome [16], respectively, thus strengthening the link between LAP1 and heterochromatinization. This evidence concerns the gene TOR1AIP1 and Congenital myasthenic syndromes.