The LAP1 E482A mutation and the best characterized torsinA ΔE302/303 mutation are predicted [2,60] and known [12,61], respectively, to negatively affect the LAP1:torsinA interaction and both have been associated to dystonia [24,62], emphasizing the biological relevance of LAP1-induced torsinA activation at the NE [12,13,19]. Here, TOR1AIP1 is linked to Dystonia.