The mean concentration of HMGB1 among M0 and M1 cancer patients was 3.16 ± 0.29 and 3.44 ± 0.28 ng/mL; for HSP90, it was 16.83 ± 10.48 and 28.46 ± 7.36 ng/mL; and for S100A9, it was 5.04 ± 1.26 and 6.49 ± 2.24 ng/m, respectively. This evidence concerns the gene HMGB1 and cancer.