Our results showed that the genotypes CC, AC, and AA of the IKBKG rs2472394 variant distribution statistically significantly deviate in early AMD patients compared to the controls (89.3%, 9.3%, and 1.4% vs. 84.3%, 11.0% and 4.7%, p = 0.047), resulting in the A allele of IKBKG rs2472394 being statistically significantly less common in patients with early AMD than in controls (6.1% vs. 10.2%, p = 0.008). Here, IKBKG is linked to age-related macular degeneration.