IKBKG and hypohidrotic ectodermal dysplasia: It was also found that mutations in the IKBKG gene, also known as nuclear factor-kappa B (NF-kB) essential modulator (NEMO), are the most frequent single cause of incontinentia pigmenti (IP) in women and anhydrotic ectodermal dysplasia with immunodeficiency (EDA-ID) in men [20].