T1DM and obesity have a more complicated and not as straightforward link than obesity and T2DM [35].The excessive accumulation of body fat in individuals with type 1 diabetes is thought to be caused by non-physiological insulin replacement that results in peripheral hyperinsulinemia, insulin profiles that do not match basal and mealtime insulin needs, defensive snacking to prevent hypoglycemia, or a combination of these [36]. Here, INS is linked to obesity due to melanocortin 4 receptor deficiency.