As shown in the chart, adenocarcinoma NOS and adenocarcinoma NOS with an additional tumor component (such as synchronous: cecum(mucinous) and rectum (adenocarcinoma NOS); adenocarcinoma NOS and adenocarcinoma with intra- and extracellular mucin production; or MiNEN with an exception) exhibit a marked immune response. Here, MUC5AC is linked to adenocarcinoma.