This treatment gap, particularly in people with obesity and insulin resistance, could be at least partially overcome with GLP-1 and GIP/GLP-1 receptor agonists, as this clinical setting calls for weight loss (indirect anti-inflammatory action) and a potential direct anti-inflammatory action of these medications to reduce asthma exacerbations, possibly through some of the described mechanisms. Here, GLP1R is linked to obesity due to melanocortin 4 receptor deficiency.