Macrophages-related cytokines facilitate cystic renal cell proliferation or renal fibrosis in ADPKD via TGF beta,. IL-17 TNF alpha, IFNγ [2,45]IL-23 mediate cyst formation. via IL-12/IFN, IL-23/IL-17,STAT/JAK signaling [33,41]. IL-35 supress Th cells activity) [44]. The gene discussed is IL23A; the disease is autosomal dominant polycystic kidney disease.