MKI67 and obesity due to melanocortin 4 receptor deficiency: In the multivariate analysis, obesity (OR: 0.52, 95%CI: 0.28–0.97; p = 0.04) and low Ki-67 score (HR: 2.7, 95%CI: 1.37–5.53; p = 0.003) were independently significantly associated with a decreased rate of pCR (Figure 1).