NOS2 and Sepsis: This would suggest that independently of the mechanism of ROS and NOS production (iNOS- or NOX2-mediated) and the physiopathological mechanisms that are triggered during sepsis and that will be discussed in detail by organ in the following paragraphs, oxidative damage to DNA represents the event to which this entire process leads and, in fact, in literature, is directly related to sepsis-dependent mortality [22,23].