S100B and Sepsis: However, and precisely, thanks to the complex of manifestations that distinguish the two phenomena, in theory the post-mortem diagnosis, useful for the forensic identification of the cause of death in those cases in which it is not possible to access the clinical documentation of the patients, could, through immunohistochemical or biochemical tests, focus on the identification of specific markers of head trauma, compared to sepsis, such as aquaporins, S100 calcium-binding protein β (S100β), and neuron-specific enolase (NSE) [66,67].