CRH and systemic inflammatory response syndrome: A major consequence of systemic inflammatory response syndrome in the case of sepsis involves the increased production of neuroinflammatory cytokines, which can lead to damage to the blood-brain barrier (BBB), alterations in neurotransmission, and instability in the functioning of neurohormones, such as acetylcholine, γ-aminobutyric acid, β-endorphin, and corticotropin-releasing hormone.