While investigating the relationship of HF with the severity of TR, Lau et al. [78] studied data of patients admitted to the cardiology unit of a tertiary hospital with a diagnosis of left, right, or congestive HF, and found that the elevation of the cholestatic profile was significantly associated with the degree of tricuspid incompetence, i.e., patients with moderate or severe TR had significantly greater ALP, GGT, and bilirubin than those with no or mild TR, but not ALT or AST. Here, GPT is linked to tricuspid valve insufficiency.