A hallmark of these lymphomas is the chromosomal translocation of the c-Myc oncogene and immunoglobulin locus regulatory elements (t(8;14)) between c-Myc (8q24) and the immunoglobulin heavy chain gene on chromosome 14q32 (IGH-14q32) [15], but c-Myc rearrangement is positive in other high-grade lymphomas, such as high-grade B-cell lymphoma (HGBL), not otherwise specified (NOS). The gene discussed is MYC; the disease is lymphoma.