Factors significantly associated with depression among HIV-positive patients on antiretroviral therapy included employment status [AOR  =  0.22 (95% CI 0.13–0.36)], the patient’s highest CD4 count [AOR  =  6.99 (95% CI 2.81–17.38)], duration of months on antiretroviral therapy [AOR  =  5.05 (95% CI 2.38–10.74)], and the presence of chronic non-communicable diseases [AOR  =  7.90 (95% CI 4.21–14.85)]. Here, CD4 is linked to depressive symptom measurement.