The group particularly exposed to the development of AKI requiring the use of RRT and death are primarily hemodynamically unstable patients requiring the supply of catecholamines, with elevated preoperative and postoperative values of markers of cardiac damage, such as troponin T and NT-proBNP, as well as with elevated values of preoperative CRP levels and in old age. The gene discussed is CRP; the disease is acute kidney injury.