It has been shown that metformin can improve metabolic and hormonal profiles in patients with PCOS, such as fasting insulin, lipid parameters, testosterone, luteinizing hormone (LH)/follicle stimulating (FSH) ratio, sex hormone-binding globulin (SHBG), the glucose–insulin ratio, and prolactin [6]. The gene discussed is PLOD1; the disease is polycystic ovary syndrome.