BGN and Marfan syndrome: Additional genes include those involved in ECM function and homeostasis, including Fibrillin-1 (Fbn1), Lysyl oxidase (Lox), Biglycan (Bgn) associated with MFS [83], Procollagen type III α1 (Col3a1) associated with vascular EDS and Elastin (Eln) usually associated with CLS [84,85].