LDLR and triple-A syndrome: There are also many affected loci associated with genes involved in lipoprotein handling and metabolism in AAA, including the Sortilin-1 (Sort1) gene associated with plasma low-density lipoprotein (LDL)/cholesterol handling [112] and the LDL/cholesterol receptor (Ldlr) gene associated with LDL/Cholesterol handling [5,111,113] (Table 2).