Mutations in the Low-density lipoprotein receptor (Ldlr) gene are generally seen in various dyslipidemic states such as familial hypercholesterolemia [160], type III hyperlipidemia [161] and most recently, within a subset of mutations that can increase susceptibility to aneurysm development, found at 19p13.2 genetic locus [5,113]. The gene discussed is LDLR; the disease is familial hypercholesterolemia.