Pregnancy is inherently a hypercoagulable state that results from increased levels of coagulation factors I (fibrinogen), VII, and VIII; von Willebrand factor; and factor X. Pregnant women also experience decreased free protein S (a natural anticoagulant), increased acquired resistance to activated protein C, and decreased fibrinolysis, owing to increased levels of plasminogen activator inhibitors 1 and 2, as well as increased D-dimer levels [2,3,4]. Here, PROS1 is linked to thrombophilia.