SIRT1 and diabetic kidney disease: In high-fat–high-sugar-fed Sprague Dawley rats that were treated with streptozotocin, liraglutide (0.6 mg/kg/day) for 12 weeks reduced albuminuria, and the authors suggested that liraglutide may have a renoprotective effect in DKD through its effect on the Micro RNA-34A (miR-34a)/sirtuin 1 (SIRT1) pathway [27].