In Sprague Dawley rats fed a high-sugar and high-fat diet and injected with low-dose streptozotocin to induce type 2 diabetes, liraglutide (0.2 mg/kg/12 h) for eight weeks had a renoprotective effect by activating forkhead box protein O1 (FoxO1) [30]. Here, FOXO1 is linked to type 2 diabetes mellitus.