In contrast, cancers with low CDX2 showed higher SOX2 expression (mean expression z-score relative to all samples = 0.42, Student’s t test p < 0.0001) and significant HNF4A suppression (mean expression z-score relative to all samples = −1.07, Student’s t test p < 0.0001, Figure 3). This evidence concerns the gene SOX2 and cancer.