Gastric cancers with CDX2 induction and a parallel induction of HNF4A (defined as mRNA expression z-score relative to all samples above 1) showed an even lower percentage of diffuse histology (3.1%) compared with all cancers with CDX2 induction (diffuse histology in 11.2% of cases, Table 6) or the cohort with no CDX2 induction (diffuse histology in 24.2%). The gene discussed is HNF4A; the disease is gastric cancer.