Given its estrogenic activity, BPA may interact with various endocrine systems and metabolic pathways, while bisphenol analogs may exert similar effects on metabolic pathways, promoting insulin resistance and hyperinsulinemia through chronic inflammation, which in turn leads to increased secretion of GnRH and LH, as seen in PCOS [42]. The gene discussed is PLOD1; the disease is Hyperinsulinemia.