Given its estrogenic activity, BPA may interact with various endocrine systems and metabolic pathways, while bisphenol analogs may exert similar effects on metabolic pathways, promoting insulin resistance and hyperinsulinemia through chronic inflammation, which in turn leads to increased secretion of GnRH and LH, as seen in PCOS [42]. This evidence concerns the gene GNRH1 and polycystic ovary syndrome.