INS and atherosclerosis: Thus, in addition to the imbalance toward vasoconstriction, the vascular risk profile in patients with diabetes and atherosclerosis also depends on the imbalance toward hypercoagulability through the loss of coagulative homeostasis (which certainly depends in part on hyperglycemia but could also depend on the increased release of proinsulin degradation products in the mechanism of conversion to insulin) [112].