Sepsis is a severe clinical syndrome due to the host response to infection, exacerbated by the production of both pro-inflammatory cytokines (TNF-alpha, IL-1-beta>alpha, IL-6, il-8, IL-12, IL-17, COX-2, IRF3) and anti-inflammatory (IL-10) cytokines [25]. The gene discussed is IL17A; the disease is Sepsis.