Polymorphisms on cytokine genes (i.e., TNF-alpha 1-2 alleles and IL-1Ra 1-2 alleles) have their impact on the course of sepsis, showing an increased severity of the infection in TNF2 carriers and in IL-1Ra2 (associated with higher levels of IL-1 and lower levels of IL-1Ra). This evidence concerns the gene TNF and Sepsis.