On the contrary, histological analysis revealed loss of AQP2 expression in the collecting ducts in patients with elevated bilirubin and cholemic nephropathy (CN), and consequently, the loss of AQP2 in such patients might be the result of toxic effects of cholestasis and in part be responsible for the impairment of renal function [208]. Here, AQP2 is linked to cyclic hematopoiesis.