Moreover, the anti-inflammatory effect of KLF4 in ECs has been shown to improve the condition of patients with vascular lesions due to ischemic stroke by regulating the endothelial expression of other inflammatory cell adhesion molecules such as E-selectin, intercellular adhesion molecule 1 (ICAM-1), as well as VCAM-1, NF-kB, and tight junction proteins [47]. Here, ICAM1 is linked to ischemic stroke.