In the MPTP-induced mouse PD model with LPS/ATP and activated BV2 and N2a microglia cell lines, the increased expression of MALAT1 was accompanied by upregulation of proinflammatory cytokines and the components of NLRP3 inflammasome (nucleotide oligomerization domain-like receptor family, pyrin domain containing 3), including NLRP3, ASC, and cleaved caspase 1 proteins, and downregulation of nuclear factor (erythroid-derived 2)-like-2 factor (Nrf2) transcript. Here, MALAT1 is linked to Parkinson disease.