Recent preclinical research was conducted to explore the use of CNS-specific estrogen-like 10b-17β-dihydroxyestra-1,4-dien-3-one (DHED), which had neuroprotective effects on the 3K mice male PD model as it enhanced motor symptoms, increased the rate of α-synuclein tetramerization in relation to the α-synuclein monomer, and enhanced the dopaminergic and cortical neurons neurite complexity [32]. The gene discussed is SNCA; the disease is Parkinson disease.