Within normal germinal center B cells, EZH2 has several possible overlapping functional roles as follows: (1) promoting cellular proliferation by repressing tumor suppressor genes; (2) mimicking the repression state found in stem cells, allowing for the prevention of premature cell differentiation; and (3) maintaining the transcriptional repression status found in malignant B cells [11]. This evidence concerns the gene EZH2 and neoplasm.