The research conducted by Głowińska et al. has demonstrated that in children with obesity, hypertension, and diabetes, elevated levels of sICAM-1, sVCAM-1, and E-selectin are indicative of endothelial activation, a predictor of the early stages of atherosclerosis [43]. The gene discussed is SELE; the disease is obesity due to melanocortin 4 receptor deficiency.