HIF1A and COVID-19: The gene expression level of hypoxia-inducible factors-1α (HIF-1α), a main player in the cellular response to hypoxia and OxS, was significantly increased in the v-COVID-19 (p = 0.04, 1.9-fold increase) and u-COVID-19 (p = 0.019, 1.2-fold increase) placentae compared to the v-CTRL subgroup (Figure 1B), and in the v-COVID-19 subgroup relative to the u-CTRL subgroup (p = 0.02, 1.6-fold increase) (Figure 1B).