In the present study, we investigated the placental antioxidant asset, involving CAT and SOD enzymes, comparing (a) vaccinated vs. unvaccinated COVID-19-positive women during the third trimester of pregnancy, and (b) vaccinated or unvaccinated COVID-19-positive pregnant women vs. vaccinated or unvaccinated COVID-19-negative pregnant women. Here, SOD1 is linked to COVID-19.