In conclusion, given the lack of promising preventive treatment of retinal pathologies in ocular diseases (such as diabetic retinopathy, central retinal artery occlusion, age-related macular degeneration, or glaucoma), administration of amino acids, either alone or in association with current ophthalmic drugs (especially anti-VEGF antibodies) or other promising nutrients (such as vitamins or minerals), could prevent retinal damage by improving systemic metabolic regulation. This evidence concerns the gene VEGFA and diabetic retinopathy.