INS and Alzheimer disease: An increase in proteins involved in the transport and uptake of insulin-like growth factor (IGF) has also been described in healthy women compared to men, but in the case of Alzheimer’s disease, there is a decrease in proteins involved in the response to insulin stimulus and in the regulation of insulin secretion by GLP1 (glucagon-like peptide-1), some of which are involved in GABAergic synapses and circadian synchronization.