VEGFA and neoplasm: Zhao et al. have demonstrated that intravenous administration of As2O3 encapsulated in liposomes leads to a 5-fold increase in arsenic concentrations in rat brains in comparison to a single administration of As2O3, and ultimately induces apoptosis and suppresses tumor angiogenesis via interfering with the expression of vascular endothelial growth factor (VEGF) with low toxicity [89].