ATP1A1 and glioblastoma: In addition, Lan and colleagues have demonstrated that bufalin inhibits GBM cells growth by expediting proteasomal degradation of the Na+/K+-ATPase α1 subunit (ATP1A1), known to exert important roles in tumorigenesis of GBM, and apoptosis, both of which are closely linked to the p53 signaling pathway [145,146].