Although GATA3 serves as a practical immunohistochemical marker for differentiating cancers with urothelial origins from prostate cancers, GATA3 positivity in metastatic prostate PCa may infrequently lead to misdiagnosis, necessitating a panel of immunohistochemical markers, for both prostatic and urothelial cancers and primary and metastatic tumors [49]. The gene discussed is GATA3; the disease is prostate carcinoma.