GATA3 and neoplasm: Interestingly, GATA3 activity is not limited to regulation and reprograming seen in genetically and clinically unique groups of T-cell lymphoproliferative neoplasms, as recent work has provided the first direct evidence that GATA3 is, indeed, a bona fide proto-oncogene that contributes to the aggressiveness for these neoplasms [44].