Accordingly, hyperinsulinemia maintained its immunosuppressive effect in CD4+ cells of the JAKi-treated patients by mitigating upregulation of the key Th1 transcription factors RORC and PRDM1, as well as the chemokine receptors CXCR3 and CCR5 (Figure 4A). This evidence concerns the gene CXCR3 and hyperinsulinism.