We found that a summarized transcription of glycolytic enzymes G6PD, HK3, PFKFB3, PFKFB2, ALDOA, PGM1, LDHA, PGAM1, ENO1, and GAPDH comprising the glycolytic index (GI) was significantly lower in RA patients compared to HC (Figure 1B). The gene discussed is ENO1; the disease is rheumatoid arthritis.