In our adenine diet-induced CKD model, we observed evidence of early cardiovascular remodeling, including significant upregulation of key genes associated with cardiac fibrosis and inflammation, such as Collagen 1a1, Collagen 3a1, and Collagen 11a1, as well as markers of immune activation like Ccl2 and TGFβ. This evidence concerns the gene CCL2 and chronic kidney disease.