Furthermore, given that osteoporosis involves impaired bone formation and enhanced osteoclast-mediated bone resorption, investigating osteoporotic patients’ osteoclasts in the context of the beta-2-adrenergic receptor polymorphic variant, both in monoculture and in co-culture, with osteoblasts with microfluidic systems for relevant recapitulating bone tissue in vitro, could provide crucial insights into the role of the beta-2-adrenergic receptor in bone homeostasis. The gene discussed is ADRB2; the disease is osteoporosis.