In vitro, using SGC-7901 and MKN-1 gastric cancer cells, upregulation of TRIM24 protein levels induced chemoresistance to 5-Fluorouracil (5-FU) and led to an increase in phospho-AKT and cyclin D1, an effect that was counteracted by an AKT inhibitor, suggesting that TRIM24 activated the AKT pathway to induce this chemoresistance [105]. The gene discussed is AKT1; the disease is gastric cancer.