MTOR and gastric cancer: Upregulation of TRIM14 had a promotive effect on autophagy and proliferation and an inhibitory effect on apoptosis in SGC7901/5-FU cells, while TRIM14 knockdown had the reverse effect both in vitro and in vivo in a subcutaneous xenograft model of 5-FU-resistant gastric cancer in BALB/c nude mice, which can be reversed by MK3903, an agonist of the AMPK/mTOR pathway [150].