TRIM28 knockdown notably inhibited gastric cancer progression through the suppression of IDO1 both in vitro using MGC803 and 746T cells and in vivo via a subcutaneous xenograft model in BALB/c nude mice injected with MGC803 cells, while overexpression of IDO1 or SRF can counteract the TRIM28 knockdown-induced reduction in proliferation [161]. This evidence concerns the gene SRF and gastric cancer.