In addition, in hepatocellular carcinoma, PH domain and leucine-rich repeat protein phosphatase 1 (PHLPP1), an AKT phosphatase, was ubiquitinated in a K48-linked manner by TRIM11, leading to its degradation and an increase in phospho-AKT levels, thus activating the PI3K/AKT signaling pathway [102]. The gene discussed is AKT1; the disease is hepatocellular carcinoma.