Mechanistically, TRIM7 induced ferroptosis and suppressed gastric cancer progression by targeting Solute Carrier Family 7 Member 11 (SLC7A11), facilitating Lys48-linked polyubiquitination through its B30.2/SPRY domain, thus inhibiting glutathione peroxidase 4 (GPX4) level, which is crucial for cellular antioxidant defenses. This evidence concerns the gene SLC7A11 and gastric cancer.