TRIM21 and neoplasm: Meanwhile, TRIM21 also suppressed the expression of enhancer of zeste homolog 1 (EZH1), a protein playing a role in maintaining chromatin compaction, which contributes to the chemosensitivity of tumor cells in SGC7901 and BGC823 cells, where TRIM21 overexpression reduced EZH1 stability and expression levels, enhancing tumor cell chemosensitivity.